Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the syncytiotrophoblast (part of the placenta). Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions, for instance it is thought that it affects the immune tolerance of the pregnancy. Early pregnancy testing generally is based on the detection or measurement of hCG.
Human Chorionic Gonadotropin with a MW of 36.7 kDa is isolated from a sterile preparation of placental glucoprotein urine of pregnant women. hCG consists of 237 amino acids, with an alpha chain of 92 amino acids and a beta chain of 145 amino acids length.
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